Anti-Inflammatory Effects of Fatty Acid Amide Hydrolase Inhibition in Monocytes/Macrophages from Alzheimer’s Disease Patients

Fatty acid amide hydrolase – A target for anti-inflammatory therapies?

Inhibition of fatty acid amide hydrolase exerts cutaneous anti-inflammatory effects both in vitro and in vivo.

Complete List of Authors: Oláh, Attila; University of Debrecen, Department of Physiology Ambrus, Lídia; University of Debrecen, Department of Physiology Nicolussi, Simon; University of Bern, Institute of Biochemistry and Molecular Medicine, NCCR TransCure Gertsch, Jürg; University of Bern, Institute of Biochemistry and Molecular Medicine, NCCR TransCure Tubak, Vilmos; Creative Laboratory Ltd, K...

Epigenetic Regulation of Fatty Acid Amide Hydrolase in Alzheimer Disease

OBJECTIVE Alzheimer disease (AD) is a progressive, degenerative and irreversible neurological disorder with few therapies available. In search for new potential targets, increasing evidence suggests a role for the endocannabinoid system (ECS) in the regulation of neurodegenerative processes. METHODS We have studied the gene expression status and the epigenetic regulation of ECS components in ...

Regulation of inflammatory pain by inhibition of fatty acid amide hydrolase.

Although cannabinoids are efficacious in laboratory animal models of inflammatory pain, their established cannabimimetic actions diminish enthusiasm for their therapeutic development. Conversely, fatty acid amide hydrolase (FAAH), the chief catabolic enzyme regulating the endogenous cannabinoid N-arachidonoylethanolamine (anandamide), has emerged as an attractive target for treating pain and ot...

Analgesic effects of fatty acid amide hydrolase inhibition in a rat model of neuropathic pain.

Cannabinoid-based medicines have therapeutic potential for the treatment of pain. Augmentation of levels of endocannabinoids with inhibitors of fatty acid amide hydrolase (FAAH) is analgesic in models of acute and inflammatory pain states. The aim of this study was to determine whether local inhibition of FAAH alters nociceptive responses of spinal neurons in the spinal nerve ligation model of ...